Methylisothiazolinone and Fragrance mix sensitization in Iranian Children

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Here is an interesting study looking at sensitization rates in Iranian children with contact dermatitis.
Notably, most allergens appeared with higher frequency in older children except some notable exceptions:  cobalt chloride, methylisothiazolinone, paraben mix, and fragrance mix.  

The MI and the fragrance mix related chemicals are frequently used in personal hygiene products marketed for children.

Patch testing in Iranian children with allergic contact dermatitis

Hossein Mortazavi, Amirhooshang Ehsani, Seyed Sajed Sajjadi, Nessa Aghazadeh, and  Ebrahim Arian

BMC Dermatol. 2016; 16: 10.  Published online 2016 Jul 12.  PMCID: PMC4943022

“Background”

“Allergic contact dermatitis is a common disorder in adults and children alike and appears to be on the increase. The purpose of this study was to determine the sensitization trends in Iranian children with contact dermatitis.“

“For most allergens (except cobalt chloride, methylisothiazolinone, paraben mix, and fragrance mix), the percentages of positive response in the older age group (11–18 years) were higher than children below 10 years.  The most common allergen in the younger age group were cobalt chloride (4, 18.2 %), nickel sulfate (3, 13.6 %), methylisothiazolinone (2, 9.1 %), and paraben mix (2, 9.1 %) while in the older group they were as follows: nickel sulfate, cobalt chloride, methylisothiazolinone, colophony, potassium dichromate.“

Read more here:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4943022/