Collection of Blogs related to information about contact dermatitis

Free Article: MCI-MI ‘Outstanding Emerging Allergen’ Thailand

/1 Comment/in /by

This article from King Chulalongkorn Memorial Hospital in Thailand compares the authors patch test result between current (2012-2015) and their prior report (2003-2004).  The authors named MCI-MI an “outstanding emerging causative allergen” in their current clinical experience and found MCI-MI to be the most common preservative causing contact allergy (formaldehyde is second).  The MCI-MI prevalence was found to be related to personal care products.  Also of importance,  the prevalence of paraben (another preservative) allergen dropped possibly related to decreased exposure and decreased use in products.
Patterns and risk factors of causative contact allergens in Thai adult patients with contact dermatitis at King Chulalongkorn Memorial Hospital.  Dararattanaroj W1, Pootongkam S, Rojanawatsirivej N, Wongpiyabovorn J.  Asian Pac J Allergy Immunol. 2016 Jun 30. doi: 10.12932/AP0757.

“BACKGROUND:
Surveillance on common allergens identified by patch testing plays an important role in emerging allergen detection, which leads to both individual and societal level prevention.
OBJECTIVE:
To study the changes in the pattern of contact sensitization and to identify risk factors associated with allergens.
METHOD:
The data of 206 patients who underwent patch testing at King Chulalongkorn Memorial Hospital during 2012 to 2015 were assessed. The associations between patient risk factors and positive reactions to each allergen were evaluated. The results were compared with data from 2003-2004.
RESULTS:
The top five most common allergens during 2012-2015 were nickel sulfate (19.4%), methylchloroisothiazolinone/ methylisothiazolinone (MCI/MI) (13.6%), fragrance mix I (FM I) (10.7%), carba mix (9.2%) and cobalt chloride (6.3%) whereas, during 2003-2004, these were nickel sulfate, cobalt chloride, FM I, potassium dichromate and Myroxylon pereirae. A positive patch test to nickel was strongly associated with a history of metal and seafood allergy (p±0.001; OR, 4.94; 95% CI = 2.33-10.47 and p=0.028; OR, 2.55; 95% CI, 1.11-5.85, respectively). MCI/MI was correlated with a history of personal care products allergy, and fragrance was correlated with a history of urticaria (p=0.005; OR, 4.05; 95% CI = 1.54-10.66 and p=0.031; OR, 2.71; 95% CI, 1.10-6.68, respectively).
CONCLUSIONS:
There was an alteration in the pattern of contact sensitization detected by our standard series. MCI/MI has become the most common preservative causing contact allergy.”

Link here to read the full OPEN ACCESS article:

http://thailand.digitaljournals.org/index.php/APJAI/article/viewFile/29955/30258

To learn more about the second methylisothiazolinone epidemic – click here:

https://www.dermatitisacademy.com/wp-content/uploads/2016/05/Update-on-Isothiazolinones.pdf

 

Also:

Bunyavaree M1, Kasemsarn P1, Boonchai W1.  Cosmetic preservative labelling on the Thai market.
Contact Dermatitis. 2016 Apr;74(4):217-21. doi: 10.1111/cod.12520. Epub 2016 Jan 22.

” International brand cosmetics were more likely to contain non-formaldehyde-releasing preservatives than domestically produced brands. Isothiazolinone-based preservatives, which are responsible for the current increase in the prevalence of contact allergy, were found at a significant frequency in domestically produced, leave-on cosmetic products.”

Free Article – American Contact Alternatives Group (ACAG) – Miscellaneous

/in /by

Part 4 of a 4-part series Miscellaneous Products:

Scheman A, Jacob S, Katta R, Nedorost S, Warshaw E, Zirwas M, Selbo N.Trends and Alternatives in Deodorants, Antiperspirants, Sunblocks, Shaving Products, Powders, and Wipes: Data from the American Contact Alternatives Group.J Clin Aesthet Dermatol. 2011 Oct;4(10):35-9.

“To provide updated data on the usage of ingredients that are common potential contact allergens in several categories of topical products. To identify useful alternative products with few or no common contact allergens….Percentages of American Contact Dermatitis Society core series allergens (and other common preservatives and sunblocks) were calculated….Data on allergens and alternatives for ancillary skin care products are not widely published. This article reviews some of the common potential allergens in antiperspirants, deodorants, shaving products, sunblocks, powders, and wipes. Suitable available alternative products for patients with contact allergy are listed.”

Free Access to the article here:http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3196302/

ACD to cigarettes – Balsam of Peru and Chocolate fragrance

/in , /by

“Additives to Cigarette Tobacco…

Cocoa Products

Cocoa and cocoa products are used as a main flavor additive in the Philip Morris cigarette brands (Philip Morris USA, Richmond, VA)-Virginia Slims, Marlboro, and Parliament (Table 2).[10]Cocoa is from the Sterculiaceae family (also called the Malvaceae family). Cocoa beans are processed into cocoa powder to make chocolate.[11] Individuals who are allergic to balsam of Peru or fragrance mix are encouraged to avoid chocolate as part of the [LOW] balsam of Peru diet because chocolate can cause their dermatitis to flare. Salem and Fowler reported that of their patients who had positive patch-test reactions to balsam of Peru or fragrance mix, 47% had a “complete or significant improvement” in their dermatitis on the balsam of Peru diet.[12] In addition, the cocoa in cigarettes contains alkaloids that can alter how the body processes nicotine. For example, theobromine (a component of chocolate), is a bronchodilator and increases the amount of cigarette smoke inhaled.[13]

In their case report of airborne ACD from cigarettes, Kato and colleagues postulated that the allergen was “volatile” because the patient had a positive reaction to unsmoked tobacco and a negative reaction to smoked tobacco.[6] In particular, it was noted that the patient’s specific brand of cigarettes contained a chocolate fragrance.[6] The patient had only a positive patch-test reaction to her brand of cigarettes, and she recovered when she stopped smoking. This case report implies that chocolate may be an airborne allergen in cigarettes.”

Furthermore:

“Cigarette Filters, Filter Adhesives, and Cigarette Paper

Cigarette filters and cigarette paper could also be sources of airborne ACD. Philip Morris lists more than 75 ingredients in cigarette paper and filter paper”!

And!

Colophony:

“resins and rosins are found in the filter paper and monogram ink…”
Read more here: http://www.medscape.com/viewarticle/589970_3

New article came out on isothiazolinone cross reactivity (mice)

/in /by
Br J Dermatol. 2016 Jun 25. doi: 10.1111/bjd.14825. [Epub ahead of print]

Cross-reactivity between methylisothiazolinone, octylisothiazolinone and benzisothiazolinone using a modified local lymph node assay.

Schwensen JF1, Menné Bonefeld C2, Zachariae C3, Agerbeck C2, H Petersen T2, Geisler C2, E Bollmann U4, Bester K4, D Johansen J1.

Author information

Abstract

BACKGROUND:

In the light of the exceptionally high rates of contact allergy to the preservative methylisothiazolinone (MI), information about cross-reactivity between MI, octylisothiazolinone (OIT) and benzisothiazolinone (BIT) is needed.

OBJECTIVES:

To study cross-reactivity between MI and OIT, and, MI and BIT.

METHODS:

Immune responses to MI, OIT and BIT were studied in vehicle and MI-sensitised female CBA mice by a modified local lymph node assay. The inflammatory response was measured by ear thickness, cell proliferation of CD4+ and CD8+ T cells and CD19+ B cells in the auricular draining lymph nodes.

RESULTS:

MI induced significant, strong, concentration-dependent immune responses in the draining lymph nodes following the sensitisation phase of three consecutive days. Groups of MI sensitised mice were challenged on day 23 with 0.4% MI, 0.7% OIT and 1.9% BIT; concentrations corresponding to their individual EC3-values. No statisticly significant difference in proliferation of CD4+ and CD8+ T cells was observed between mice challenged with MI in comparison to mice challenged with BIT and OIT.

CONCLUSION:

Our data indicate cross-reactivity between MI, OIT and BIT, when the potency of the chemical was taken into account in choice of challenge concentration. This means that MI sensitised individuals may react to OIT and BIT if exposed to sufficient concentrations. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.

http://www.ncbi.nlm.nih.gov/pubmed/27343839

Free Article – American Contact Alternatives Group (ACAG) – Hair Products

/in /by

The American Contact Alternatives Group evaluates allergen trends and alternative products – Check out the free article here:

Part 2 of a 4-part series Hair Products: Trends and Alternatives: Data from the American Contact Alternatives Group. Scheman A, Jacob S, Katta R, Nedorost S, Warshaw E, Zirwas M, Bhinder M J Clin Aesthet Dermatol. 2011 Jul;4(7):42-6.

…
“To provide updated data on usage of ingredients that are common potential contact allergens in several categories of hair products. To identify useful alternative products with few or no common contact allergens.  — Data on allergens and alternatives for hair products is not widely published. This article reviews some of the common potential allergens in hair products, including shampoos, conditioners, and styling products. Suitable available alternative products for patients with contact allergy are listed.”

Access the FREE article here: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140904/

Free Article – American Contact Alternatives Group (ACAG) – Facial Cosmetics

/in , /by

The American Contact Alternatives Group evaluates allergen trends and alternative products – Check out the free article here:

Part 1 of a 4-part series:

Facial Cosmetics: Trends and Alternatives: Data from the American Contact Alternatives Group.

Scheman A, Jacob S, Katta R, Nedorost S, Warshaw E, Zirwas M, Cha C.

“To provide updated data on usage of ingredients that are common potential contact allergens in several categories of facial cosmetics. To identify useful alternative products with few or no common contact allergens.”

“Data on allergen usage and alternatives for facial cosmetics is not widely published. This article reviews some of the common potential allergens in facial cosmetics, including blushers and bronzers, concealers, eyeliners, eyeshadows, foundations, loose and pressed powders, and mascaras. Suitable available alternative products for patients with contact allergy are listed.”

Check out the FREE article here:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3140901/