pediatric patch test

Free Access for 30d! Inaugural Pediatric Contact Dermatitis Registry Data.

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New Today – 10 years in collaborative effort!  The inaugural data paper from the Pediatric Contact Dermatitis Registry (PCDR).   In the not too distant past it was believed that contact dermatitis (allergic) in children was rare, we now know that not to be the case as in fact it is an common in patch tested children as adults.  This study discusses the evaluation of more than 1000 US children who presented for evaluation of contact dermatitis.  The  reported here through a collaborative effort of more than 80 providers!  65% of the cases had a positive allergen and 48% were able to find at least on relevant source – remove the allergen and improve the dermatitis!!!

Goldenberg A1, Mousdicas N, Silverberg N, Powell D, Pelletier JL, Silverberg JI, Zippin J, Fonacier L, Tosti A, Lawley L, Wu Chang M, Scheman A, Kleiner G, Williams J, Watsky K, Dunnick CA, Frederickson R, Matiz C, Chaney K, Estes TS, Botto N, Draper M, Kircik L, Lugo-Somolinos A, Machler B, Jacob SE.  Pediatric Contact Dermatitis Registry Inaugural Case Data.  Dermatitis. 2016 Sep-Oct;27(5):293-302.

Abstract
BACKGROUND:
Little is known about the epidemiology of allergic contact dermatitis (ACD) in US children. More widespread diagnostic confirmation through epicutaneous patch testing is needed.
OBJECTIVE:
The aim was to quantify patch test results from providers evaluating US children.
METHODS:
The study is a retrospective analysis of deidentified patch test results of children aged 18 years or younger, entered by participating providers in the Pediatric Contact Dermatitis Registry, during the first year of data collection (2015-2016).
RESULTS:
One thousand one hundred forty-two cases from 34 US states, entered by 84 providers, were analyzed. Sixty-five percent of cases had one or more positive patch test (PPT), with 48% of cases having 1 or more relevant positive patch test (RPPT). The most common PPT allergens were nickel (22%), fragrance mix I (11%), cobalt (9.1%), balsam of Peru (8.4%), neomycin (7.2%), propylene glycol (6.8%), cocamidopropyl betaine (6.4%), bacitracin (6.2%), formaldehyde (5.7%), and gold (5.7%).
CONCLUSIONS:
This US database provides multidisciplinary information on pediatric ACD, rates of PPT, and relevant RPPT reactions, validating the high rates of pediatric ACD previously reported in the literature. The registry database is the largest comprehensive collection of US-only pediatric patch test cases on which future research can be built. Continued collaboration between patients, health care providers, manufacturers, and policy makers is needed to decrease the most common allergens in pediatric consumer products.

Full free access to the article for 30 days:

http://journals.lww.com/dermatitis/Abstract/2016/09000/Pediatric_Contact_Dermatitis_Registry_Inaugural.10.aspx

European Society CD Meeting – highlights

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This week marked the Manchester UK, European Society of Contact Dermatitis Meeting 14-17 September 2016…  There was so much top notch research presented  by international researchers.

Poster P016: Octylisothiazolinone is a relevant nonoccupational contact allergen in leather goods and may show cross-reactivity to methyisothiazolinone.   J. Leysen et al.

Poster P020: Airborne bullous allergic contact dermatitis from MI contained in a glass shower screen cleaning spray.  M.A Pastor-Nieto et al.

Poster P021: Allergic contact dermatitis from nickel is prevented using a novel barrier cream.  Niklasson B and Isaksson M.  New nickel prevention cream!  “We present a male worker with ACD due to exposure to nickel-containing tools and where an active barrier cream containing a strong metal chelating agent helped solved the problem.   … The leather gloves were analyzed for the release of nickel ions: one glove released 0.4ug nickel cm2 and the other 0.2ug nickel cm2. … The barrier cream, NIK-L-BLOKTM (Chemotechnique), captures the nickel ions using a strong chelating agent, diethylenetriaminepentaacetic acid, in a special formulation that immobilizes the nickel ions (as well as cobalt and chromium ions), thereby preventing allergic contact dermatitis.”

Poster P022 The methyisothiazolinone epidemic: a pan- European prospective study JF Schewensen et al. “Patients were exposed to the following products containing MI (and could be exposed to more than one category): dish-washing liquids (n=32), shampoo (n=30), bath/shower gel (n=22).  … Thirteen experienced an allergic reaction in newly painted rooms: ACD [skin] (n=11), rhinitis [nose] (n=2) and conjuncitivitis [eye] (n=1).  Eight (4.7%) experienced reactions to other airborne exposures than paint, for example cleaning agents… EFFECTIVE REGULATION OF MI IN COSMETIC AND OCCUPATIONAL PRODUCTS IS NOT YET IN PLACE.  The current data demonstrate the URGENT need for PREVENTIVE actions.”

These poster abstracts are printed and the articles are forthcoming.  It is critical to work with manufacturers, consumers, patient advocates (medical providers) and legislators to protect!!!

Free Article- Cosmetic Contact Allergens by An Goossens!

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This is a FREE open access article that discusses common and not so common allergens in cosmetics.  Section  3.2.2. discusses preservatives:

“Shifts in frequency of positive patch-test reactions have occurred over the years [6 ], but more

recently methylisothiazolinone (MI), in particular … weaker sensitizer… less efficient …

hence larger use concentrations … severe skin lesions and atypical clinical

symptoms, leading to a delay in the correct diagnosis (e.g., [8 ]), and respiratory …”

“The incidence of positive reactions to formaldehyde—”

3.21. discusses fragrances:

“Myroxylon pereirae (balsam of Peru), colophonium, hydroperoxides of limonene and linalool, terpene compounds that act as prehaptens…”

 

Cosmetic Contact Allergens

By An Goossens

“This article presents trends in the frequency of cosmetics as causal factors of allergic contact dermatitis during a 26-year period in 14,911 patients patch-tested between 1990 and 2014, and discusses the cosmetic allergens identified during the last six years (2010–2015) in 603 patients out of 3105 tested. The data were retrieved from, and evaluated with, a patient database developed in-house. The results show the increasing importance of cosmetic allergies, up to 25% of the patients tested during the last five-year period. As expected, fragrance materials, preservatives, and hair dyes were the most frequent culprits, but a great variety of other allergenic ingredients were involved as well. This underlines the need of additional and extensive patch testing with the patient’s products used and their ingredients.”

 

To read more click on this link:

http://www.mdpi.com/2079-9284/3/1/5

and download FREE pdf.
To learn more about contact dermatitis visit us at:

 http://www.dermatitisacademy.com